How To

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This overview is for educational use only and assumes you're working in a research setting with proper materials and safety protocols.

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Please read the important information on our main How To page before continuing.

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🧪 Step-by-Step Instructions for Using Retatrutide

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Important: Retatrutide is an investigational peptide. It is not approved for general use outside clinical trials. Always follow local laws and safety protocols.

 

1. Gather Your Supplies

You’ll need:

• Retatrutide peptide (glass vial containing 10mg of peptide powder)

• Bacteriostatic or saline water, for reconstitution (this is sterile and safe to be used for injections. Once opened, any unused water must be discarded, do not keep any open water for later use)

• Alcohol swabs (these are used to wipe the skin of the injection site and the vial's rubber top before use)

• Sterile syringe with fixed needle (most people use a 1ml/100IU (international units) syringe with a fixed, 30g needle - these are very fine and cause minimal discomfort)

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All required supplies are available to purchase from our store​.

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Ensure you are working on a clean, flat surface and that you have washed your hands with warm, soapy water and have thoroughly dried your hands with a clean, dry towel.

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2. Preparing Retatrutide for Injection

Retatrutide is sold and shipped as a dry powder in a sterile, vacuum sealed glass vial. Retatrutide can not be sold pre-mixed as it would become expired if not properly refrigerated between mixing and dosing.

• Clean the area of the bacteriostatic/saline vial that you will pierce with the needle as well as the rubber seal of the Retatrutide vial (remove the plastic cap) with an alcohol swab.

• Draw your required dose of bacteriostatic or saline water slowly into your syringe. Most people mix 10mg of Retatrutide with 1ml/100 units (a full syringe) basteriostatic/saline water.

• Slowly inject the water into the Retatrutide vial, letting it run down the side to avoid damaging the peptide. (ensure there are no air bubbles in the syringe)

• Gently swirl (don’t shake) until fully dissolved.

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3. Calculate Your Dosage

• Retatrutide dosing is commonly 25 units every 6 days (a quarter of a 1ml/100unit syringe) for the first month.

  • if you feel the side effects are too harsh on you, reduce the dose until you find a happy medium between desired results and side effects, for example you may inject 12.5units every 4 days or you may inject 20units every 6 days​

• After the first month, it is common to increase up to 50 units every 6 days (half of a 1ml/100unit syringe).​

• Use a dosage calculator (linked on our main "how to" page or chart to determine how much volume (in mL or IU) corresponds to this with your setup.

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4. Administer the Dose

• Retatrutide is typically administered via subcutaneous injection (under the skin).

• Ensure there are no air bubbles in the syringe when administering your dose, air bubbles can cause an inaccurate dose reading and can lead to complications. Clear air bubbles by tipping the filled syringe upside down (needle at top) and slowly pushing the syringe in until a tiny drip comes out of the needle.

• Clean the injection site (abdomen or thigh - a fatty area) with an alcohol swab.

• Pinch the skin, insert the needle at a 45-degree angle, and inject slowly.

• Dispose of the syringe safely.

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Retatrutide use should not exceed 1 use per week for 8 weeks on, followed by an 8 week break.

 

Storage and Safety

• Store reconstituted Retatrutide in the fridge (2–8°C).

• Use within 5 weeks of mixing.

• Keep all materials sterile and dispose of sharps properly.

• Do not pre-make syringes.

• Do not re-use syringes.